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The client’s physi-cal and mental statuses will determine how much of the totalexam you may perform at one time. This is an important concept becauseeven though relatively small amounts of chemicals cross theskin, they can be sufficient to cause local and/or systemictoxicity.

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Unfortunately, there is no clear guideline for this. lidocaine (t? 1.5 hr) used forcardiac arrhythmias is given as an i.v. Starting atthe fourth month, these layers become very thinto facilitate the exchange of products across the placental barrier.

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